neminly asked:


A lot of the teens on the skin care board are really using a lot of benzoyl peroxide. Should these products maybe state on the label or something that benzoyl peroxide is used to induce skin cancer in lab animals for skin cancer research?
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=2507187&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
Department of Dermatology Skin Diseases Research Center, University Hospitals of Cleveland, OH.
It is known that the free-radical-generating compound, benzoyl peroxide (BPO) enhances malignant conversion of murine skin benign papillomas into carcinomas.
If there is such a difference between rodent and human skin, why are they using the rodents to test skin cancer drugs for humans? What, the results of the drug tests are okay and helpful for humans but how we get it is different?
FDA MedWatch…

Benzoyl peroxide has been shown to be a tumor promoter and progression agent in a
number of animal studies. The clinical significance of this is unknown.
Benzoyl peroxide in acetone at doses of 5 and 10 mg administered twice per week induced
skin tumors in transgenic Tg.AC mice in a study using 20 weeks of topical treatment.
In a 52 week dermal photocarcinogenicity study in hairless mice, the median time to onset
of skin tumor formation was decreased and the number of tumors per mouse
increased following chronic concurrent topical administration of BenzaClin Topical Gel
with exposure to ultraviolet radiation (40 weeks of treatment followed by 12 weeks of
observation).

http://www.fda.gov/medwatch/SAFETY/2005/APR_PI/BenzaClin_PI.pdf
If it is used to turn benign papillomas (like a pimple) to malignant papillomas in lab animals at ONLY 5-10% applied ONLY 2 times a week from ONE source, How can the chem manufacturer state that it doesn’t?